Your screenshot cannot tell really what's going on.
May be it's time for a backup.
If I recall on MS Windows, E: can be another partition or an external HDD? (sorry, more than a decade i ditched Windows thus I might not remembering well)
If it's an external storage, you may want to check the connection/wire of your HDD/SSD, if this happens with other software, time to check this partition/HDD.
Also I noticed the folder "steamapps", does steam have access to it (to update for example)? if so you might also want to look into this path.
May be it's time for a backup.
If I recall on MS Windows, E: can be another partition or an external HDD? (sorry, more than a decade i ditched Windows thus I might not remembering well)
If it's an external storage, you may want to check the connection/wire of your HDD/SSD, if this happens with other software, time to check this partition/HDD.
Also I noticed the folder "steamapps", does steam have access to it (to update for example)? if so you might also want to look into this path.